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Nicotinamide mononucleotide (NMN)

is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+)
and fulfills a crucial role in the provision of energy in the cells.

NMN (nicotinamide mononucleotide) is, according to German and
European law, it is a chemical that is not suitable for human consumption.
The application is therefore only for studies, research purposes and laboratory tests in the life science sector.
CAS: 1094-61-7, molecular formula (Hill Notation): C11H15N2O8P, PubChem Substance ID: 24897645.

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Additional information

MSM
Synonym(s): dimethylsulfone, methylsulfonylmethane, sulfonylbismethane, Natural organic sulfur compound.

Occurrence in food
Methylsulfonylmethane (MSM) is a biological compound that, as part of the diet, serves as a sulfur supplier to the human organism. Sources of the sulfur-containing substance are foods such as milk, meat and fish. However, heating, drying and other processing methods destroy MSM.

Physiological effects
Sulfur metabolism: Central role in sulfur metabolism and starting material for S-adenosylmethionine, N-acetylcysteine, glutathione or taurine.
Antioxidant: sulfur compounds support antioxidant reactions

MSM – a natural component of the diet
Methylsulfonylmethane (MSM) is a biological compound that, as part of the diet, serves as a sulfur supplier to the human organism. It can be formed as a physiological oxidation product from dimethyl sulfoxide (DMSO) and represents the central starting material for orthomolecular substances such as S-adenosylmethionine, N-acetylcysteine, glutathione or taurine. This makes it an important part of the body’s sulfur metabolism (1). The therapeutic effect of sulfur compounds is partly due to antioxidant protective reactions enabled by the sulfur contained in these molecules. In addition, endogenous sulfur compounds are needed to stabilize tertiary structures in proteins (2). The latter is seen as a rationale for the chondroprotective properties of MSM.

The properties of MSM
Sulfur-containing substances have long been used in pain therapy. MSM is suitable for therapeutic use especially for pain associated with osteoarthritis, arthritis or sports injuries. The mechanism of action discussed is an aspirin-like approach explained by inhibition of cyclooxigenase (COX) (3). It is also said to shorten the recovery time of overtrained muscles and help injuries heal faster. Improved results with concomitant vitamin C supplementation have also been reported.

References:
Micronutrient Coach® – The great BIOGENA compendium of nutrients. 4th ed. Verlagshaus der Ärzte, Editors: Dr. Christina Schmidbauer and Georg Hofstätter MSc.